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A Multicentre Comparative Trial of Sodium Valproate and Carbamazepine in Adult Onset Epilepsy JNNP 57:682-687, Richens,A.,et al, 1994 See this aricle in Pubmed Article Abstract The long term efficacy and safety of sodium valproate and carbamazepine in adult outpatients with newly diagnosed primary generalized or partial and secondarily generalized seizures were compared in a randomized,open, multicentre study at 22 neurology outpatient clinics.Sodium valproate and carbamazepine controlled both primary generalized and partial seizures equally effectively overall.Sodium valproate and carbamazepine were both associated with a high degree of overall seizure control regardless of seizure type and both have good long term tolerability in adult patients with newly diagnosed epilepsy.Recommendations are made for a higher initial dosage regime for sodium valproate in partial seizures.

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(click to filter results - removes previous filter) carbamazepine seizure seizure,psychomotor-temporal lobe seizure,tonic-clonic seizure,treatment of sodium valproate treatment of neurologic disorder

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